Michael J O'Neill Selected Research

(R)- 4'- (1- fluoro- 1- methyl- 2- (propane- 2- sulfonylamino)- ethyl)- biphenyl- 4- carboxylic acid methylamide

1/2005	LY503430: pharmacology, pharmacokinetics, and effects in rodent models of Parkinson's disease.
8/2003	LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease.

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Michael J O'Neill Research Topics

Disease

16	Alzheimer Disease (Alzheimer's Disease) 11/2023 - 01/2004
16	Parkinson Disease (Parkinson's Disease) 10/2017 - 09/2002
6	Schizophrenia (Dementia Praecox) 03/2012 - 06/2004
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 02/2007
4	Tauopathies 01/2020 - 09/2011
3	Mental Disorders (Mental Disorder) 01/2018 - 06/2004
3	Cognitive Dysfunction 02/2017 - 06/2004
3	Disease Progression 09/2011 - 11/2002
2	Mitochondrial Diseases (Mitochondrial Disease) 03/2008 - 03/2006
2	Epilepsy (Aura) 03/2004 - 08/2002
2	Seizures (Absence Seizure) 03/2004 - 08/2002
1	Hypokinesia (Bradykinesia) 01/2018
1	Atrophy 03/2016
1	Amyloid Plaque 01/2016
1	Gaucher Disease (Gaucher's Disease) 12/2015
1	Inflammation (Inflammations) 12/2015
1	Weight Loss (Weight Reduction) 09/2011
1	Neuroblastoma 02/2007
1	Gliosis 01/2006
1	Infarction (Infarctions) 12/2003

Drug/Important Bio-Agent (IBA)

6	AMPA Receptors (AMPA Receptor)IBA 05/2007 - 08/2003
5	Amyloid (Amyloid Fibrils)IBA 11/2020 - 10/2014
4	Biomarkers (Surrogate Marker)IBA 11/2023 - 10/2004
4	Oxidopamine (6 Hydroxydopamine)IBA 12/2013 - 03/2006
3	Glutamic Acid (Glutamate)FDA Link 08/2012 - 08/2002
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2016
2	tau Proteins (tau Protein)IBA 01/2020 - 01/2016
2	Levodopa (L Dopa)FDA LinkGeneric 01/2018 - 02/2012
2	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 12/2013
2	alpha-SynucleinIBA 10/2017 - 12/2015
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 05/2015 - 10/2004
2	NeurotoxinsIBA 05/2015 - 03/2006
2	Methylazoxymethanol AcetateIBA 03/2012 - 01/2012
2	RotenoneIBA 02/2012 - 03/2008
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 03/2007 - 10/2004
2	LY 404187IBA 02/2007 - 02/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2007 - 10/2004
2	Ketamine FDA LinkGeneric 10/2006 - 05/2006
2	(R)- 4'- (1- fluoro- 1- methyl- 2- (propane- 2- sulfonylamino)- ethyl)- biphenyl- 4- carboxylic acid methylamideIBA 01/2005 - 08/2003
2	Neuroprotective AgentsIBA 01/2005 - 08/2003
2	metabotropic glutamate receptor 2IBA 04/2004 - 09/2002
2	gamma-Aminobutyric Acid (GABA)IBA 03/2004 - 08/2002
2	Pilocarpine (Ocusert)FDA LinkGeneric 03/2004 - 08/2002
2	LY 379268IBA 03/2004 - 09/2002
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 03/2004 - 01/2004
1	Aquaporin 4IBA 01/2020
1	Reserpine (Serpasil)FDA Link 01/2018
1	Immune Checkpoint InhibitorsIBA 01/2018
1	SynucleinsIBA 10/2017
1	CalpainIBA 03/2016
1	CalciumIBA 03/2016
1	Doxycycline (Periostat)FDA LinkGeneric 03/2016
1	SphingolipidsIBA 12/2015
1	Glucosylceramidase (Glucocerebrosidase)IBA 12/2015
1	Peptides (Polypeptides)IBA 10/2014
1	2-amino-4-phosphonobutyric acidIBA 08/2012
1	pyridineIBA 03/2012
1	Antimitotic AgentsIBA 03/2012
1	N- (1- methylethyl)- 5- (pyridin- 4- ylethynyl)pyridine- 2- carboxamideIBA 03/2012
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 02/2012
1	3,4-Dihydroxyphenylacetic AcidIBA 02/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012
1	Sirtuin 3IBA 01/2012
1	DNA (Deoxyribonucleic Acid)IBA 01/2012
1	Alkylating AgentsIBA 01/2012
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2011
1	AntibodiesIBA 09/2011
1	Mitogen-Activated Protein KinasesIBA 01/2009
1	Caspase 3 (Caspase-3)IBA 03/2008
1	Protein Kinases (Protein Kinase)IBA 03/2008
1	Phosphotransferases (Kinase)IBA 03/2008
1	CaspasesIBA 03/2006
1	alpha7 Nicotinic Acetylcholine ReceptorIBA 01/2006
1	Cholinergic Agents (Cholinergics)IBA 01/2006
1	amyloid beta-protein (1-42)IBA 01/2006
1	Dopamine Agonists (Dopamine Agonist)IBA 10/2004
1	JNK Mitogen-Activated Protein KinasesIBA 10/2004
1	Dihydroxyphenylalanine (Dopa)IBA 10/2004
1	3,9-bis((ethylthio)methyl)-K-252aIBA 10/2004
1	3,4-dihydroxyphenylglycolIBA 03/2004
1	Anticonvulsants (Antiepileptic Drugs)IBA 03/2004
1	LigandsIBA 03/2004
1	Dialysis SolutionsIBA 03/2004
1	Amino Acids FDA Link 03/2004
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2004
1	Protons (Proton)IBA 12/2003
1	Carboxylic AcidsIBA 08/2003
1	AcidsIBA 08/2003
1	PropaneIBA 08/2003
1	diphenyl (biphenyl)IBA 08/2003
1	HexanesIBA 09/2002
1	Kainic Acid Receptors (Kainate Receptor)IBA 08/2002

Therapy/Procedure

10	Therapeutics 09/2017 - 08/2002
1	Immunotherapy 09/2011